Products
Biointegrative nerve guide
SILKBridge® is a biointegrative nerve guide engineered to advance peripheral nerve repair through the unique capabilities of silk fibroin. Its proprietary Tri-Layer™ architecture and semipermeable wall design provide structural support for axonal growth while enabling cellular infiltration, remodeling, and natural integration with native tissue. Designed to balance mechanical integrity, flexibility, and handling, SILKBridge offers surgeons a soft, off-the-shelf implant intended to support repair with both biologic sophistication and procedural simplicity.
SILKBridge® PROPERTIES
TENSION AT THE REPAIR SITE?
SILKBridge® axial deformation profile at physiological value of stress mimics the behaviour of natural nerves².
COMPRESSIVE STRESSES?
SILKBridge® protects the growing nerve from compressive stresses
LACK OF MECHANICAL COMPLIANCE ACROSS THE JOINTS?
The multilayered structure of SILKBridge® ensures biomechanical compliance at the implantation site¹.
Tri-Layer design 1,2,3,4,5
The 3D architecture of SILKBridge® shows two working mechanisms in one device. SILKBridge® is specifically designed with the aim for the electrospun components (inner and outer layers made of regenerated silk) to promote cells recruitment and adhesion while the textile component (middle layer made of native silk) stays still to support the natural nerve healing process.
Tri-Layer design 1,2,3,4,5
The 3D architecture of SILKBridge® shows two working mechanisms in one device. SILKBridge® is specifically designed with the aim for the electrospun components (inner and outer layers made of regenerated silk) to promote cells recruitment and adhesion while the textile component (middle layer made of native silk) stays still to support the natural nerve healing process.
THE INTERMEDIATE WOVEN CORE
provides mechanical strength and stability, supporting tensile loading, suture retention, and resistance to compression.
THE INNER AND OUTER ELECTROSPUN
layers are designed promote cell adhesion, resorb faster.
New Biointegrative Mechanism of Action 1,2,3,4,5
SILKBridge's proprietary physio-chemistry demonstrates neovascularization and native tissue ingrowth combined with optimized enzymatic bioabsorption. SILKBridge induces neo-angiogenesis.
Unique cellular Environment
PROPRIETARY PHYSIO-CHEMISTRY
2 WEEKS
Early cell infiltration, regenerated nerve fibers associated with Schwann cells
4 WEEKS
Blood vessels with erythrocytes, visible throughout
12 AND 24 WEEKS
Regrowing myelinated fibers organized in microfascicles, with well-defined axoplasm and wellorganized myelin sheaths